How does synaptogenesis occur

Binder, Nobutaka Hirokawa, Uwe Windhorst. Contents Search. Authors Authors and affiliations Masumi Ichikawa. How to cite. Synonyms Synapse formation. This is a preview of subscription content, log in to check access. Cohen-Cory S The developing synapse: construction and modulation of synaptic structures and circuits. Science — PubMed Google Scholar. Ferreira A, Paganoni S The formation of synapses in the central nervous system.

Abbas L Synapse formation: lets stick together. Curr Biol —27 Google Scholar. Synaptic pruning is an essential part of brain development. By getting rid of the synapses that are no longer used, the brain becomes more efficient as you age.

Today, most ideas about human brain development draw on this idea of brain plasticity. Researchers are now looking into ways to control pruning with medications or targeted therapy. Researchers are also studying how the shape of the synapses might play a role in mental disabilities. The process of synaptic pruning may be a promising target for treatments for people with conditions like schizophrenia and autism.

However, research is still in the early stages. You can improve your brain health with the right diet. Eat these 11 foods to boost your memory and focus, help prevent disease, and keep sharp as you…. In the autism community, weighted blankets are often used to provide comfort to restless or stressed individuals. But what does the research say? Experts say ageism in the medical industry is growing.

They urge older adults to prepare for their appointments and bring along an advocate. Getting more birthdays under your belt? That doesn't mean you have to stop working out. You can find shower chairs in some local stores. Here's what to keep in mind when you're shopping online or in person. Also called an elevated toilet seat, a raised toilet…. Learn about end-of-life signs in older adults, and the timeline for experiencing them.

We also review how to best support your loved one physically…. Health Conditions Discover Plan Connect. What Is Synaptic Pruning? Medically reviewed by Karen Gill, M. How does synaptic pruning work? When does synaptic pruning occur?

Does synaptic pruning explain the onset of schizophrenia? Is synaptic pruning associated with autism? Hall, D. Kinesin-related gene unc is required for axonal transport of synaptic vesicles in C. Cell 65 , — Hallam, S. Hammarlund, M. Mutations in beta-spectrin disrupt axon outgrowth and sarcomere structure. Harrington, R. Harris, T. Mutations in synaptojanin disrupt synaptic vesicle recycling. Hedgecock, E. Motor vesicles. Huang, C. Laminin alpha subunits and their role in C. Kishi, M. Mammalian SAD kinases are required for neuronal polarization.

Science , — Ko, J. Koushika, S. A post-docking role for active zone protein Rim. Liao, E. An SCF-like ubiquitin ligase complex that controls presynaptic differentiation. Nature , — Loria, P. A conserved postsynaptic transmembrane protein affecting neuromuscular signaling in Caenorhabditis elegans. Murthy, V. Cell biology of the presynaptic terminal. Nakata, K. Cell , — Nguyen, M. Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase.

Genetics , — Nonet, M. Visualization of synaptic specializations in live C. Methods 89 , 33— UNC , a Caenorhabditis elegans AP homologue, regulates the size and protein composition of synaptic vesicles.

Cell 10 , — Norman, K. Alpha spectrin is essential for morphogenesis and body wall muscle formation in Caenorhabditis elegans. O'Grady, P. The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR. Ohtsuka, T. Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc Ozaki, N. Pappas, G. Structure and Function of Synapses. Raven Press, New York. Patel, N.

Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain. USA 90 , — Patton, B. Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice. Richmond, J. UNC is required for synaptic vesicle fusion in C.

Rongo, C. LIN is a shared component of the polarized protein localization pathways in neurons and epithelia. Cell 94 , — Rostaing, P. Preservation of immunoreactivity and fine structure of adult C.

Saifee, O. The Caenorhabditis elegans unc locus encodes a syntaxin that interacts genetically with synaptobrevin. Cell 9 , — Sakamoto, R. Schaefer, A. Neuron 26 , — Scheiffele, P. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons.

Schoch, S. RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Schuske, K. Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin. Serra-Pages, C. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. Shen, K. The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C.

Signor, D. Two heteromeric kinesin complexes in chemosensory neurons and sensory cilia of Caenorhabditis elegans. Sorra, K. Overview on the structure, composition, function, development, and plasticity of hippocampal dendritic spines. Hippocampus 10 , — Tam, T. Voltage-gated calcium channels direct neuronal migration in Caenorhabditis elegans. Wan, H. Highwire regulates synaptic growth in Drosophila. Wang, Y.

A family of RIM-binding proteins regulated by alternative splicing: implications for the genesis of synaptic active zones.

USA 99 , — Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Weimer, R. Defects in synaptic vesicle docking in unc mutants. White, J. The structure of the nervous system of the nematode C.

Wyszynski, M. Neuron 34 , 39— Yamagata, M. Synaptic adhesion molecules. Yeh, E. Identification of genes involved in synaptogenesis using a fluorescent active zone marker in Caenorhabditis elegans. Zhai, R. The architecture of the active zone in the presynaptic nerve terminal. Physiology Bethesda 19 , — Zhao, H. A retrograde signal is involved in activity-dependent remodeling at a C.

Zhen, M. Regulation of presynaptic terminal organization by C. The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C.